International Consensus Guidelines for the Diagnosis and Management of Food Protein-Induced Enterocolitis Syndrome

Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma, and Immunology

Journal of Allergy and Clinical Immunology     
Publication Date: March 2017

These guidelines cover the diagnosis and management of Food Protein-Induced Enterocolitis Syndrome (FPIES). The guidelines aim to improve the consistency of support and information provided to patients with FPIES.

Learn more about the development and release of the guidelines here.

Who Are They For?

Healthcare professionals who care for patients with FPIES

Patients with FPIES and their families and caregivers

Any and all professionals that may encounter FPIES patients and families


The guidelines include recommendations on:

  • Definition and Clinical Manifestations

  • Epidemiology, Diagnosis

  • Gastrointestinal Manifestations

  • Acute Management

  • Nutritional Management

  • Natural History

  • Future Needs


The International FPIES Association has a global dissemination plan in place for the guidelines that includes outreach to various clinician groups, including allergists, gastroenterologists, pediatricians, and ER physicians, allied health professionals, nurses, dietitians, as well as parents and relevant advocacy groups. There will also be a national outreach plan to reach every allergist in the United States.

For international outreach, the I-FPIES medical advisors and executive board will be traveling to major society meetings to educate providers worldwide, and the guidelines will be made available in many languages through the organization’s partnerships

View and Share Full Guidelines

The FPIES guidelines are available open access in the Journal of Allergy and Clinical Immunology.

View and Share Position Paper

The position paper offers a 20-page summary of the full FPIES guidelines

View and Share Guidelines

The front side of the guidelines brochure, which highlights the 30 Summary Statements included in the full FPIES guidelines.