Diagnosis and Testing

Food Protein-Induced Enterocolitis Syndrome (FPIES) affects primarily young children, particularly during infancy with the early introduction of additional foods.


Treatment and Managing Reactions

If you have an accidental exposure, fluid rehydration and potentially the administration of ondansetron is key. If you are able to tolerate fluids by mouth, small sips of fluids every few minutes can be beneficial.


Hypotension and Shock

It is estimated that up to 10% of FPIES reactions in adults may result in low blood pressure or shock. The term “shock” is used to refer to poor blood circulation from a variety of causes. It is not completely understood why FPIES reactions sometimes lead to low blood pressure.


Oral Food Challenge

The oral food challenge (OFC) is performed to assess resolution of FPIES. It is important to have a shared decision-making process on proceeding with the OFC. It should be discussed with the patient that depending on the severity of the past FPIES reaction, it may be necessary to place a peripheral IV prior to starting the oral food challenge.

Related Conditions

Adults with FPIES have significantly higher rates of atopic diseases. Allergic rhinitis, asthma, atopic dermatitis are conditions that occur more frequently in patients with FPIES.