I-FPIES Launches Enhanced Website to Mark 13th Anniversary

Food protein -Induced Enterocolitis Syndrome

What is FPIES?

Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE mediated food allergy of the gastrointestinal system.

Approximately 2-4 hours after ingesting a trigger food, patients experience profuse vomiting often leading to dehydration which may necessitate the need for emergency fluid resuscitation. 20% of patients experience hypovolemic shock.There are currently three FPIES phenotypes: acute, chronic and atypical.

The International Consensus Guidelines for the Diagnosis and Treatment of FPIES determined that first foods of introduction are the most common triggers in infants and children geographically. The most commonly reported triggers in adults are seafood and mollusks. Any food (even those thought to be hypoallergenic e.g. rice, avocado) can cause an FPIES reaction. FPIES typically starts within the first year of life, but adult onset is reported in the literature.

K52.21 is the official ICD-10 code FPIES.


US Pediatric FPIES prevalence rate


US Adult FPIES prevalence rate


Total people in US with lifetime history of FPIES

Nowak-Wegrzyn A, Warren CM, Brown-Whitehorn T, Cianferoni A, Schultz-F, Gupta RS. Food protein-induced enterocolitis syndrome in the US population-based study. J Allergy Clin Immunol. 2019 Oct;144(4):1128-1130. doi: 10.1016/j.jaci.2019.06.032. Epub 2019 Jul 6. PMID: 31288044; PMCID: PMC7923683.

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ICD-10 Code: K52.21

IFPIES achieves medical classification as listed by World Health Organization (WHO) under the range - Diseases of the Digestive system.

FPIES added to the Consortium for food Allergy Research (CoFAR)

IFPIES thanks the National Institutes of Health (NIH) and the National Institute of Allergy and Infectious Diseases (NIAD) for their partnership and representation of the full food allergy landscape.

NIH awards $2.5 million grant to study FPIES

IFPIES Medical Advisory Board Chair Dr. Anna Nowak-Wegrzyn and Dr. Cecila Berin to study the immunology of FPIES in the hopes to lead to a diagnostic test and better treatment options. By deciphering the mechanisms of FPIES reactions.

IFPIES leads the international Consensus Guidelines for the Diagnosis and Management of FPIES

Available Open Access in the Journal of Allergy in Clinical Immunology, this 99 page document aims to improve consistency of support and information provided to patients with FPIES.

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Meet our Team

Our medical advisory board


Anna Nowak-Wegzryn, MD, PhD

New York, NY
Terri Brown Whitehorn

Terri Brown-Whitehorn, MD

Philadelphia, PA

Scott Sicherer, MD

New York, NY
Antonella Muraro

Antonella Muraro, MD, PhD

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